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When to Flag the Combination to Your Prescriber Tell your dermatologist or prescriber before starting omega-3s if you: Take aspirin, NSAIDs, clopidogrel, warfarin, apixaban, or rivaroxaban Have a personal or family history of bleeding disorders Are scheduled for surgery or a procedure within the next 30 days Have platelet counts below 100,000/mm on recent bloodwork Pharmacokinetic Considerations: Absorption and Timing Does Omega-3 Change Isotretinoin Blood Levels