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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Liver transaminase elevations are observed less frequently with ICIs than skin or gastrointestinal toxicities, but relatively high rates have been reported with the ipilimumab and nivolumab combination or high-dose ipilimumab therapy (Eggermont et al., 2015

The integration of peptides with other therapeutic modalities and the development of personalized medicine approaches may further enhance their clinical utility