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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

This totally subjective study that lacked the necessary control group(s) concluded that, in 14 of the patients, intraarticular injection of BPC-157 helps with multiple types of knee pain. In a similar 2014 study that also lacked any controls, the same group reported that BPC 157 was effective in relieving the pain associated with interstitial cystitis (bladder pain) in 10 of 12 women