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doi: 10.3389/fendo.2013.00174 50 KrassasGEPerrosP

118 Cancer Elevated levels of ROS resulting from homeostasis imbalance are among the leading causes of the transformation of normal cells into cancerous cells

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Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, et al

People who live in areas with low levels of selenium or iodine, where a baseline shortage increases response because resolving baseline deficits can enhance antioxidant selenium enzyme activity (selenium), restore thyroid hormone synthesis and metabolism (iodine), and possibly lower thyroid autoimmunityas a result, effect sizes may seem larger in deficient settings than in replete populations [2,18,36,47]