FDA scientists said they could find little data on the effectiveness of peptides for proposed medical uses like ulcerative colitis, wound healing and opioid addiction
[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed
See Sikiric et al., Curr Pharm Des, 2018 (PMID:30246642) for an overview of the reported mechanisms, and Chang et al., J Appl Physiol, 2011 (PMID:21030673) for a representative tendon-fibroblast study
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Research trials often employ a once-weekly subcutaneous micro-dosing approach, typically around 0.1 mL, to maintain consistent exposure levels in peptide models
