Progress will depend on decoupling lesion efficacy from systemic exposure through lesion-focused delivery platforms, triggerable or receptor-targeted prodrugs, and schedules or combinations that sustain lesion pressure at reduced doses
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Normally, MOR activation suppresses GABAergic signaling, leading to increased activity in glutamatergic pyramidal neurons 32,33,34
To manage the risk of elevated transaminase levels, assess ALT and AST: within one month prior to initiation of XENPOZYME, within 72 hours prior to any infusion during dose escalation, which includes the first 3 mg/kg dose, or prior to the next scheduled XENPOZYME infusion upon resuming treatment following a missed dose
C.Agudelo-DelgadoM.TobnG