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These inflammatory proximal tubular cells can significantly downregulate GSH metabolic genes, making cells more prone to ferroptosis, resulting in repair failure after kidney injury, ultimately promoting kidney fibrosis and the progression of AKI to CKD (209)

However, genes are not your destiny and you can overcome the potential health risks associated with the MTHFR gene mutation through dietary, lifestyle, and supplement modifications

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Another antifungal medication, amphotericin B, shows a heightened risk for new-onset dilated cardiomyopathy and subsequent heart failure, but these symptoms can be reversed by discontinuing this medication