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Similarly, ketamine has been shown to be effective in inducing long-lasting changes in synaptic plasticity in depression-like behaviors in several models, including chronic corticosterone (CORT) associated with repetitive restraint stress [30], anxiety disorders associated with post-traumatic stress disorder (PTSD) [31], chronic pain [32], and middle cerebral artery occlusion associated with chronic unanticipated mild stress [33]

A comprehensive panel of antibodies was utilized for Western blotting, targeting phosphorylated and total forms of ERK1/2, p38 MAPK, JNK1/2, and NF-B p65 (Ser536), with -actin serving as a loading control

Arch Toxicol 70(5):310

GSH reduction can occur in both (intrinsic) mitochondrial-mediated apoptosis and (extrinsic) death receptor-mediated apoptosis based on tumorigenesis by two possible mechanisms: gene mutation and transcription factors (TF)