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Starting with lower doses, keeping detailed notes on effects, and being prepared to discontinue if unexpected responses occur represents a prudent approach

424 Cytoplasmic NADH from the glycolytic pathway is delivered to mitochondria through two NADH shuttles, G3P shuttle and MA shuttle, allowing NAD + recycling to sustain glycolytic flux

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Factors affecting response include: Duration of hair loss (recent loss responds better than long-standing)

TABLE 1 Causes of vitamin B12 deficiency, classified by cause