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bound to TC Excessive vitamin B 12 in the circulation, e.g., such as after injections, usually exceeds the binding capacity of TC and is excreted in the urine

So they did all kinds of horrible things to these mice

Results Association of peptide proteoforms with age, sex and post-mortem interval Nontryptic mass spectrometry was performed on 102 human cortical samples obtained post-mortem from the angular gyri of individuals stratified into four diagnostic classes: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)

PMID 15188752

Circulation 103 , 113118