Increased levels of miR-141 expression in hepatocellular carcinoma cells such as HepG2, SMMC-7721, and HuH7 cell lines has shown to downregulate Keap1 expression via the Keap1 3 untranslated region (3 UTR), resulting in transcriptional activation of Nrf2-dependent HO-1 gene (Shi et al., 2015)
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The development of nanotechnology-based formulations, such as liposomes and nanophytosomes, has shown great promise in enhancing the solubility, stability, and brain bioavailability of these compounds, thereby maximizing their neuroprotective effects in ASD (Moghaddam et al., 2023