The antioxidant properties of carotenoids are related to conjugated double bonds which can accommodate unpaired electrons and extensively delocalize them over the conjugated system of double bonds (Mortensen et al
Because mitochondria utilize about 90% of inhaled oxygen, they are highly vulnerable to free radical oxidative damage
59 In a crossover trial in 40 patients with primary open-angle glaucoma or normal tension glaucoma being treated with a topical prostaglandin analog, IOP decreased and tests of retinal function improved after supplementation with 600 mg PEA daily in addition to topical treatment for four months
In the neurogenic niche, astrocytes express ciliary neurotrophic factor (CNTF), while the receptor, CNTFR, is predominantly expressed in neural progenitor cells and hippocampal neurons [22]
A central objective of pro-oxidant therapeutic strategies is to trigger ferroptosis a distinct, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation
