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Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritis

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Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation

In any case, the here reported beneficial effects of FOXO4-DRI provide a wide range of possibilities for studying the potential of therapeutic removal of senescence against diseases for which few options are available