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BMC Genomics 18 , 478 (2017)

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Reducing the dosage mitigates the specific reaction

The differentiation of preNeus to mature neutrophils is characterized by a change in the shape of the nucleus: promyelocytes (round nuclei) - metamyelocytes (kidney-shaped nuclei) - immature neutrophils (banded nuclei) - mature neutrophils (classical segmented nuclei)

trial participants must also report directly to the trial sponsor and principal investigator