Today, DSIP is primarily studied as a peptide of interest in neuropeptide pharmacology, signaling pathway investigation, and molecular regulatory network research
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In the acidic environment of endosomes, the lowered pH facilitates the release of Fe from the Tf-TfR1 complex, allowing TfR1 and apotransferrin (apoTF) to be recycled back to the cell surface (Klausner et al., 1983
HK2 upregulation induces H3K18la, which promotes glycolysis and M1 polarization of liver macrophages by enriching glycolytic gene transcription in MASLD patients and mouse models, thereby establishing a positive feedback loop that exacerbates MASLD
Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy