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Early synaptic dysfunction or synaptopathy at the level of inhibitory interneurons within the entorhinal cortex and CA3 hippocampal subregion leads to hyperactivity of pyramidal cells, which appears to play a role in the progression of AD neuropathology (e.g., tauopathy) (271, 272)

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A refrigerator with a verified 2 to 8 degrees Celsius range, ideally with a thermometer or data logger covering the four-week reconstitution window

"Cyanocobalamin reductase / alkylcobalamin dealkylase (MMACHC, Human)"

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