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The activation of microglial cells by A deposition promotes the production of proinflammatory and cytotoxic factors, such as TNF-, IL-1, IL-6, interferon-gamma (IFN-), transforming beta growth factor (TGF-), chemokines and macrophage inflammatory protein (Yan et al., 2021)

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[168] showed that the ability of PET fragments to interact with cell membranes is strongly size-dependent: PET monomers readily inserted into phospholipid bilayers from the aqueous phase, whereas PET tetramers did not penetrate the membrane, implying higher passive-diffusion potential and thus greater bioavailability for smaller particles

Le, T.M., et al., gamma-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo