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The following day the prepulse-inhibition of startle response was assessed by exposing rats to a startle stimulus (105 dB for 20 ms) preceded (100 ms) by a pre-pulse (77, 80 and 83 dB for 10 ms) repeated 10 times for each prepulse intensity at pseudo-random interval (1520 s, average of 17.5 s)

They accumulate in tumors without affecting normal tissue, inhibiting tumor growth and extending life (median survival time doubled) when combined with an alternating magnetic field ( In vitro assays demonstrated increased cytotoxicity against human and mouse cell lines, and a 3D spheroidal model revealed decreased TMZ efflux across the blood-brain barrier (BBB) measured by trans-endothelial electrical resistance

Severe allergic reactions and anaphylaxis have been reported [see Adverse Reactions (6)]

Flagg EW, Coates RJ, Jones DP, et al

Res 81 , 249258 (2017)