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169 In Staphylococcus aureus , Cu negatively modulates flux through the pentose phosphate pathway by direct binding to phosphoribosylpyrophosphate synthetase (Prs), which synthesizes phosphoribosyl diphosphate (PRPP), a key metabolite that is used to synthesize the purine and pyrimidine nucleobases and nicotinamide dinucleotides

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Standard cycle lengths Recommended GHK-Cu cycle lengths typically range from 4 to 16 weeks, with 8-12 weeks being most common