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6-8 A few epidemiologic studies have also found a correlation between increased hemoglobin levels and increased vaso-occlusive crisis (VOC) frequency, 9,10 and a phase 3 study of senicapoc (ICA-17043) was stopped early due to lack of efficacy in terms of reduction of VOCs despite an observed increase in hemoglobin and decrease in hemolysis
Supplementation with cysteine and glutamine can restore GSH function, thereby inhibiting ROS-induced death in LAMP2-knockout RPECs (168)
an inhibitor of GCL and consequently of glutathione synthesis) enhanced ferroptotic cell death induced by all ferroptosis-inducing compounds, and its modulation effect is specific to ferroptosis-inducing compounds
B., Vandenberghe, LPd
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