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When cortisol levels are consistently and chronically elevated, the body can impair the production of other hormones in order to meet this demand for elevated cortisol

Additionally, old DCs express lower levels of CCR7 and CCR9, resulting in decreased migratory activity, as demonstrated in studies on aged mice [255]

J Clin Endocrinol Metab 81:33523359 Vaccarello MA, Diamond FB Jr, Guevara-Aguirre J, Rosenbloom AL, Fielder PJ, Gargosky S, Cohen P, Wilson K, Rosenfeld RG (1993) Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/laron syndrome

This is particularly concerning if you monitor your blood glucose infrequently