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specifically, the end-product, GSH, accumulates in the cell and acts as an inhibitor of -glutamylcysteine ligase activity, thereby preventing the overproduction of GSH 41 (Figure 2)

Recent studies have shown that circulating BDG levels are linked to immune activation and inflammation in people living with chronic conditions that induce epithelial gut damage and subsequent microbial translocation such as CMV and HIV infections ( Circulating monocytes serve as an integral part of the host response to infections by detecting PAMPs, phagocytosing/presenting antigens, and producing pro-inflammatory cytokines/chemokines to help recruit a larger wave of diverse leukocytes to the site of infection