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Under basal conditions, NRF2 is kept at a low cellular concentration by the activity of Keap1, its major regulator, keeping the expression of NRF2-regulated genes at low levels in order to preserve the correct redox homeostasis [152]

Furthermore, in newborn rats, P4 treatment lessened inflammation, with fewer activated microglia in the cortex and hippocampus following hypoxia-induced brain injury

Williams, T.D., & Bradley, M.A

This process not only alleviates the oxidative stress of the wound, but more importantly, the O 2 produced, as a key substrate, greatly alleviates the hypoxic state of the wound bed, thereby significantly enhancing the SDT efficacy of the sonosensitized agent PCN-224 and enabling it to efficiently generate ROS to kill bacteria

AD patients also display additional biomarkers including cerebrovascular pathology and vascular dysfunctions, decreases in cerebral blood flow, cerebrovascular reactivity, and neurovascular coupling, leading to brain deficits in oxygen and nutrient delivery [4,5]