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(2014) 2014:CD009281

In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, and WARNINGS]

cruzi , and its inhibition increased the carbonylated protein content, resulting from formation of covalent, non-reversible lipid aldehyde adducts on side chain of cysteine, histidine, and lysine residues

Defects in the antioxidant enzyme system can lead to the accumulation of reactive oxygen derivatives [33]

Waiting to see if there are good results