Inactivating this pathway, whether spontaneously or through intervention, triggers factors that induce ferroptosis, underscoring the importance of regulating ferroptosis in cancer treatment (124)
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Mild reactions like fever (1-3% of cases) or hives respond well to antihistamines, while severe anaphylaxis occurs in less than 1 in 50,000 transfusions
In the UK, hydroxocobalamin is the standard form used for intramuscular injections, and routine monitoring of serum B12 levels during replacement therapy is generally not required once treatment is established