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Behav Brain Res 2011;221:564-73

In contrast to necroptosis, the defining event in the mitochondria-mediated necrosis is the opening of the mitochondrial permeability transition pore (mPTP) on the inner mitochondrial membrane regulated by cyclophilin D (CypD) and/or increased outer mitochondrial membrane permeability mediated by Bax and Bak 7, 8

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Schleicher U, Paduch K, Debus A, Obermeyer S, Konig T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ et al (2016) TNF-mediated restriction of arginase 1 expression in myeloid cells triggers type 2 NO synthase activity at the site of infection