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Mechanism of Action: A cholinergic parasympathomimetic agent exerting a broad spectrum of pharmacologic effects with predominant muscarinic action Indications: (Salagen ) resulting from salivary gland hypofunction caused by: Treatment of dry mouth Radiotherapy for cancer of the head and neck Sjgrens syndrome, an autoimmune disorder where immune cells attack and destroy the glands that produce tears and saliva Treatment of glaucoma (Open-Angle & Acute Angle-Closure)(Isopto Carpine ) eye drops containing pilocarpine cause contraction of the ciliary muscle which opens the trabecular meshwork spaces to increase the outflow of aqueous humor through the canal of Schlemm , thereby lowering intra-ocular pressure

Pathogenic mutation of the tartrate-resistant acid phosphatase ACP5 leads to a strong predisposition to autoimmune diseases, associated with the accumulation of phosphorylated osteopontin, involved in immune regulation and in bone resorption (138)

Practitioners should note that they only work when combined with a healthy lifestyle that promotes weight loss