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[Abstract] RTqPCR analyses demonstrated that the transcriptional upregulation of sHSP genes (17.4, 17.6A, 21, 23.5) in ClpD-GFP line #5 was suppressed by the ROS scavenging reagent GSH (500 M, 2 days)
In general, ECs are connected side-by-side through transmembrane adhesion proteins [37], including vascular endothelial and neural cadherin at adherent junctions [38, 39], occludin [40], and members of the claudin family [41], as well as the junctional adhesion molecule (JAM) family at tight junctions [42]
The cleavage-resistant mutant NDUFS1 D255A decreases ROS formation and delays the loss of plasma membrane integrity (Ricci et al., 2004), suggesting cI inhibition as an accelerator of apoptosis
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