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5.1.1 DNA methylation alterations 5.1.1.1 Aberrant imprinting and global hypomethylation Critical imprinting regions undergo substantial methylation changes following EED exposure

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One point is scored when each criterion is reached for the 9 items in the Beighton Score: Palms can rest flat on the floor during forward flexion of the trunk, standing with the knees extended, Hyperextension of the knees beyond 10 (one point for each knee), Hyperextension of the elbows beyond 10 (one point for each elbow), The thumb can be passively touched against the flexor aspect of the forearm (one point for each hand), and The 5 th finger can be extended beyond 90degrees at the metacarpophalangeal joint (one point for each hand)

If you want the biology the literature predicts, you need a delivery method that bypasses the stratum corneum