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Biosci Biotechnol Biochem 61(10):16211625 Murty NA, Tiwary E, Sharma R, Nair N, Gupta R (2011) Gamma-glutamyl transpeptidase from Bacillus pumilus KS 12: decoupling autoprocessing from catalysis and molecular characterization of N-terminal region

When applied to skin, it converts to retinaldehyde and then to retinoic acid, the active form

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The only available human clinical trial data comes from Beck et al

This process depends on the TNF signaling pathway and involves 2-hydroxyglutarate accumulation and KDM1A-mediated demethylation, identifying potential therapeutic targets for allergic asthma (146)