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People who have had allergic reactions to cobalt or cobalamin (the form of B12 in injections) should avoid them
Technical Specifications Technical Specifications Minimum Detection Limit3.763 g/mL Linear Range12.5-400 g/mL Reagents and Equipment Required but Not Provided Reagents and Equipment Required but Not Provided Analytical balance, mortar/homogenizer, low temperature centrifuge, water bath, adjustable pipette, spectrophotometer/microplate reader, micro glass cuvette or 96 well flat-bottom plate and distilled water
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Hepatology 40 , 467474 (2004)