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Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well (Kre et al., 2023), revealing a context-dependent interplay between CHAC1 and NRF2 that merits further study

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Ir-Myositis ranges from mild, with some cases resolving spontaneously upon discontinuation of the offending drug 39 , to severe peripheral and respiratory weakness requiring mechanical ventilation 40

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Our team is keeping a close eye on this litigation, and well update this post as new information is released