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It works through different central nervous system pathways and does not directly inhibit COX enzymes in the same way, making it a less disruptive choice for pain management in this context

Jin Y, Li D, Lu S, et al

10.1186/s12986-015-0044-z 56 GumeniS.PapanagnouE

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Gandhi goes on to say that while the high rate of mortality may be related to the severity of illness and underlying risk, it may also be due to chance because of the small number of participants, and that a larger, more definitive study of this drug may be warranted