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To assess the half maximal inhibitory concentration (IC50) of FOXO4-DRI on the serum limitation-induced senescent fibroblast and the non-senescent control fibroblast, the fibroblast viability in the 2% FBS induced senescent fibroblast and 10% FBS cultured non-senescent control fibroblast with increasing concentrations of FOXO4-DRI was detected, and the cell viability curves were showed in Supplementary Fig

Published veterinary research on the peptide contributed to understanding of its mechanisms and safety profile, though this animal data has not been directly replicated in human clinical trials

The studys authors emphasize the need for further clinical trials to validate these initial findings

Each patient will receive prescription medication to help combat the side effects should they arise along with directions on dosage to help keep side effects to a minimum

Research designs for agents that poison single enzymes make little sense when studying nutrients