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Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Lebers disease A current infection If youre taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections

These may include redness or irritation at the injection site

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If you are under 50 and generally healthy, and you eat a balanced/varied diet, you likely dont need to supplement

Point 1 in above link is about being under treated for B12 deficiency with neuro symptoms present