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Originally identified in a screen for compounds selectively lethal to RAS-mutant cancer cells, RSL3 triggers ferroptotic cell death by inactivating GPX4, leading to the accumulation of toxic amounts of reactive oxygen species (ROS) and subsequent oxidative membrane damage [1]

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doi: 10.1128/aem.52.3.515-519.1986 66 KanpiengjaiA.MahawanR.LumyongS.KhanongnuchC

A 2025 systematic review in the HSS Journal identified 36 studies from 1993 to 2024, with consistent findings across multiple animal models and injury types

(PubMed) Heinen MM, Verhage BA, Goldbohm RA, van den Brandt PA