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Community-reported oral doses (roughly 50150 mg/day) are not derived from any published study

doi:10.3390/ijms22168677

EZH2, the H3K27 methyltransferase responsible for gene silencing, shows 2.4-fold increased activity, reinforcing repressive chromatin states in spermatogonial cells (94)

For the early treatment throat spray, concentrations can be escalated up to 300uM at an orally/buccally tolerated pH of 9.1, which is 150x the IC 100

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