The cytotoxicity of As 2 O 3 occurred through the generation of reactive oxygen species (ROS), thus inhibiting radical scavenging systems would enhance the therapeutic efficacy of As 2 O 3 provided that normal cells were relatively resistant to such a measure
The formation of an NFT radical anion has been demonstrated in enzymatic assays following a one-electron reduction, e.g., by xanthine oxidase (Miller et al
Jill James, Paul Cutler, Stepan Melnyk, Stefanie Jernigan, Laurette Janak, David W Gaylor, and James A Neubrander
Interestingly, Choi and colleagues described decreased hepatic GSH levels, which correlated with a fall in GS activity in Tat transgenic mice (Choi et al., 2000)
Your genes play a role in how susceptible you are to damage from toxicants or nutrient deficiencies