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Additionally, many phytochemicals undergo microbial biotransformation into more bioactive metabolites, potentially enhancing efficacy while minimizing systemic toxicity

Our results showed that the contribution of the TSS pathway on de novo cysteine synthesis and GSH generation is only detectable under cystine-restricted conditions, and such function is dimmed when cystine is supplemented at supraphysiological concentrations

Similar content being viewed by others Introduction Rheumatoid arthritis (RA) is a devastating systemic autoimmune disease characterized by serious synovitis and bone loss, leading to joint destruction and deformity 1,2

Donors should also report any recent dose escalations and current symptoms, as these may affect eligibility decisions at some centers