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Hypoxia-inducible factor-1 perpetuates synovial fibroblast interactions with T cells and b cells in rheumatoid arthritis

Although the serum glycerol levels were similarly increased in WT/HFD mice and Insr P1195L/ +/HFD mice, the blood glucose levels after CL316432 administration were significantly higher in Insr P1195L/ +/HFD mice, indicating that enhanced lipolysis exacerbates hyperglycemia in Insr P1195L/ +/HFD mice

10.1177/2333721418811201 Gerontol

Quantification of the ratio of nuclear/cytosolic Nrf2 staining indicated a concentration-dependent increase in Nrf2 translocation from the cytosol to the nucleus for both NFT and DEM treatments (Fig