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Results A palbociclib whole genome CRIPSR screen reveals modulators of ferroptosis and oxidative stress that sensitise CDK4/6 inhibitors To identify mechanisms of sensitivity and resistance to CDK4/6 inhibitors in ER+ breast cancer, we performed a negative selection genome-wide CRISPR/Cas9 mutagenesis screen using a human sgRNA library containing 87,897 sgRNAs 17 and doxycycline Cas9 inducible MCF-7 cell (MCF-7 iCas9