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As TP53 mutations are strong drivers of negative outcomes in multiple hematologic malignancies, as exemplified by relapsed pediatric acute lymphoblastic leukemia, APR-246 may likely have more broad clinical implications including synergy with traditional cytotoxic agents, as has been recently described.20 Together, shedding light on the synergistic mechanisms underlying APR-246 and azacitidine therapy as presented in this study are critical to continue to advance this novel therapeutic option for patients with the poorest outcomes to traditional treatments

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Practical strategies for optimizing light exposure to support circadian rhythms and sleep [A: 1:04:00, V: 1:07:50]

It doesnt work except for a couple of them. Asprey broke down two experimental drugs he says could serve as an entry point for those looking to dip their toe into the fast-moving, still largely unregulated world of peptides

A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands