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Genetic and pharmacological models are sometimes incorporated to test pathway attribution and signaling independence

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For hormonally-driven conditions like melasma, maintenance is key, as hormonal shifts can trigger new discoloration

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Methods PaDHDPR cloning, expression, and purification The gene encoding DHDPR (residues 1264) was amplified by polymerase chain reaction (PCR) from the genomic DNA of Paenisporosarcina sp