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This extrarenal production allows tissues to generate active vitamin D independently of systemic hormone levels, explaining why adequate 25(OH)D concentrations are necessary even when circulating 1,25(OH)2D levels appear normal

doi: 10.1126/sciadv.abi6696 95 Martnez-ReyesIChandelNS

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(2019, PMID 30915550) , and it is worth noting that essentially all of that evidence is preclinical our breakdown of BPC-157's FDA approval status and the parallel TB-500 regulatory picture cover why neither compound has cleared the approval pathway