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338 The accumulation of ROS further exacerbates cellular stress by inducing genotoxic damage, which can lead to overactivation of the p53 tumor suppressor gene, driving persistent senescence and amplifying inflammatory signaling through increased cytokine and metalloproteinase production, potentially accelerating the onset or progression of RA and other age-related inflammatory conditions

Pancreatic -Cell Calcium Channels The calcium channels in the plasma membrane of pancreatic -cells belong to the voltage-gated calcium channel family

Conversely, dysbiosis of gut microbiota could enhance susceptibility to pulmonary diseases and potentially act as causative agents for respiratory infections

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16 : 24452452 Polyak K, Xia Y, Zweier JL, Kinzler Kw, Vogelstein B