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However, both mTOR and GSK3 upstream are the negative regulators of autophagy leading to failure of autophagy as in Lafora disease which is an autosomal recessive epilepsy characterized by resistance epilepsy and dementia (Lohi et al

In particular, Ras mutations induce dysregulated cell division within thyroid follicular cells, leading to hyperplastic thyroid lesions including nodules (Peterson 2014)

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