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Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism

Protein S -glutathionylation is an important post-translation modification, providing protection of protein cysteines from irreversible oxidation and, at the same time, serving to transduce a redox signal by changing structure/function of the target protein

Metabolic (e.g., AOD-9604) - fat metabolism.9 Anti-inflammatory (e.g., LL-37) - chronic inflammation regulation

The working hypothesis was straightforward: if biological ageing reflects a gradual decline in these endogenous peptide signals, then reintroducing them under controlled research conditions might offer insight into the mechanisms of cellular ageing itself

Nature 559 , 285289 (2018)