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Advanced fibrosis at diagnosis has been independently associated with a smoking history of more than 10 pack, with an odds ratio (OR) of 1.63 (95% CI 1.192.24) [62]

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GSH consists of a reduced (rGSH) and oxidized (GSSG) form, with the functional form being rGSH, which prevents cellular damage from reactive oxygen species (ROS) by becoming oxidized by glutathione peroxidase, producing GSSG and water ( M

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The heterogeneity test revealed no differences between the studies (separately, I 2 =0, 0, 0, 41, 41 and 0%, respectively)