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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

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In PD cell models, GAPDH co-localizes with -syn in Lewy bodies, accompanied by reduced GAPDH activity [70]

The sensation, sometimes described as a tightness, fullness, or like something is stuck behind the breastbone, can be temporary or persistent, painless or accompanied by other symptoms