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Administration Vitamin B12 injections are usually administered intramuscularly, often in the upper arm or thigh

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Side-effects range from mild (nausea, injection-site discomfort) to serious and even life-threatening (allergic reactions, liver injury, systemic inflammatory response, endotoxin-related events)

In each set, the time course is followed by the change from baseline (mean of days 3 to 1) to the mean of days 1-3, 7-9, and 18-20, as indicated